1
general::
Open a business, start a profession, as in Now that you've got your degree, where do you plan to set up shop? This idiom was first recorded about 1570.
American Heritage Idioms
2
general::
Phrase(s): set up shop somewhere
to establish one’s place of work somewhere. • Mary set up shop in a small office building on Oak Street. • The police officer said, "You can’t set up shop right here on the sidewalk!"
McGrawhill's American Idioms And Phrasal Verbs